Forty-two Wistar rats were divided into six groups, receiving 1% carboxymethylcellulose, 4% AA, MegaSporeBiotic™ (MSB 1 × 10 9 colony forming units/day) and MegaMucosa™ (MM 70 mg/100 g/day).

Our study aimed to evaluate, for the first time, the ability of a spore-based probiotic and an amino acid and immunoglobulin supplement in reducing tissue damage and inflammatory responses in an experimental animal model of UC. Oxidative stress and the immune response have been associated with acetic acid (AA)-induced ulcerative colitis (UC). In inflammatory bowel disease (IBD), experimental models have proven to be important tools for evaluating potential therapeutic agents and for investigating the mechanisms of pathogenesis.